![RNA as a Drug Target](https://cdn1.terrashop.org/knvpics/97/03/48/97034864N.jpg)
RNA as a Drug Target - The Next Frontier for Medicinal Chemistry
Verlag | Wiley-VCH |
Auflage | 2024 |
Seiten | 416 |
Format | 17,8 x 2,6 x 25,2 cm |
Gewicht | 948 g |
Artikeltyp | Englisches Buch |
Reihe | Methods and Principles in Medicinal Chemistry |
ISBN-10 | 3527351000 |
EAN | 9783527351008 |
Bestell-Nr | 52735100A |
Provides the concepts and tools for developing drug-like small molecules that selectively target RNA rather than proteins, including the first successful examples from the development pipeline of big pharma.
Inhaltsverzeichnis:
1. Introduction
2. RNA Structure Probing, Dynamics, and Folding
3. High Resolution Structures of RNA
4. Screening and Lead Generation Techniques for RNA Binders
5. Chemical Matter that Binds RNA
6. MicroRNAs as Targets for Small Molecule Binders
7. Pre-mRNA Splicing Modulation
8. Prospects for Riboswitches in Drug Development
9. Small Molecules That Degrade RNA
10. Approaches to the Identification of Molecules Altering Programmed Ribosomal Frameshifting in Viruses
11. RNA-Protein Interactions: A New Approach for Drugging RNA Biology
12. Drugging the Epitranscriptome
13. Outlook. A Perspective on RNA: The Next Frontier for Small Molecule Therapeutics